What is a significant risk factor for developing peripheral artery disease (PAD)?

Smoking is a significant risk factor for developing peripheral artery disease (PAD) due to its harmful effects on the vascular system. The chemicals in tobacco smoke can damage the blood vessels and contribute to the development of atherosclerosis, which is the accumulation of fatty deposits in the arteries that constrict blood flow. This process is particularly detrimental in the peripheral arteries, leading to reduced blood supply to the limbs, and can increase the risk of pain, disability, or even limb loss.

Other factors, such as a high carbohydrate diet or low cholesterol levels, can also influence cardiovascular health but are not considered as direct or significant risk factors for PAD compared to smoking. Regular exercise, on the other hand, is known to improve cardiovascular health, enhance circulation, and reduce the risk of developing conditions like PAD.